Journal article
Costs and outcomes of Lynch syndrome screening in the Australian colorectal cancer population
Dayna R Cenin, Steffie K Naber, Iris Lansdorp-Vogelaar, Mark A Jenkins, Daniel D Buchanan, David B Preen, Hooi C Ee, Peter O'Leary
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | WILEY | Published : 2018
DOI: 10.1111/jgh.14154
Abstract
Background and Aim Individuals with Lynch syndrome (LS) are at increased risk of LS-related cancers including colorectal cancer (CRC). CRC tumor screening for mismatch repair (MMR) deficiency is recommended in Australia to identify LS, although its cost-effectiveness has not been assessed. We aim to determine the cost-effectiveness of screening individuals with CRC for LS at different age-at-diagnosis thresholds. Methods We developed a decision analysis model to estimate yield and costs of LS screening. Age-specific probabilities of LS diagnosis were based on Australian data. Two CRC tumor screening pathways were assessed (MMR immunohistochemistry followed by MLH1 methylation (MLH1-Pathway)..
View full abstractGrants
Awarded by National Cancer Institute
Awarded by Australasian Colorectal Cancer Family Registry
Awarded by NHMRC
Awarded by NATIONAL CANCER INSTITUTE
Funding Acknowledgements
D. R. C., D. B. P., H. C. E., and P. O. L. are funded by the Cancer Council Western Australia Capacity and Collaboration Building Grant. The colorectal cancer data in this analysis were supported by the grant UM1 CA167551 from the National Cancer Institute and through cooperative agreements with Australasian Colorectal Cancer Family Registry (U01 CA074778 and U01/U24 CA097735) and were conducted under Colon-CFR approval C-AU-0312-01. The Melbourne Collaborative Cohort Study for colorectal cancer was funded by the NHMRC project grant 509348 (PI-Dallas English) "Risk Factors for Molecular Subtypes of Colorectal Cancer."